منابع مشابه
Natively unfolded proteins.
It is now clear that a significant fraction of eukaryotic genomes encode proteins with substantial regions of disordered structure. In spite of the lack of structure, these proteins nevertheless are functional; many are involved in critical steps of the cell cycle and regulatory processes. In general, intrinsically disordered proteins interact with a target ligand (often DNA) and undergo a stru...
متن کاملConformational Properties of Unfolded Proteins
The protein folding reaction, U(nfolded)TN(ative), is a reversible disorderT order transition. Proteins are disordered (U) at high temperature, high pressure, extremes of pH, or in the presence of denaturing solvents; but they fold to uniquely ordered, biologically relevant conformers (N) under physiological conditions. This folding transition is highly cooperative such that individual molecule...
متن کاملNatively unfolded proteins: An overview
Proteins with wholly or partly denatured structures in vivo are called intrinsically disordered or natively unfolded proteins (NUPs). Functional importance of NUPs was revealed by NMR studies as first reviewed by P. Wright in 1999. Since then, computational analyses on NUPs have also been intensively carried out to predict that approximately one third of eukaryotic proteins are NUPs. I will sta...
متن کاملUnfolded Protein Responses With or Without Unfolded Proteins?
The endoplasmic reticulum (ER) is the site of secretory protein biogenesis. The ER quality control (QC) machinery, including chaperones, ensures the correct folding of secretory proteins. Mutant proteins and environmental stresses can overwhelm the available QC machinery. To prevent and resolve accumulation of misfolded secretory proteins in the ER, cells have evolved integral membrane sensors ...
متن کاملCross-talk unfolded: MARCKS proteins.
The proteins of the MARCKS (myristoylated alanine-rich C kinase substrate) family were first identified as prominent substrates of protein kinase C (PKC). Since then, these proteins have been implicated in the regulation of brain development and postnatal survival, cellular migration and adhesion, as well as endo-, exo- and phago-cytosis, and neurosecretion. The effector domain of MARCKS protei...
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ژورنال
عنوان ژورنال: Nature
سال: 1990
ISSN: 0028-0836,1476-4687
DOI: 10.1038/348397b0